Pliant Therapeutics, Inc.
AMINO ACID COMPOUNDS AND METHODS OF USE

Abstract:

The invention relates to compounds of formula (I): ##STR00001## or a salt thereof, wherein R.sup.1, G, L.sup.1, L.sup.2, L.sup.3, and Y are as described herein. Compounds of formula (I) and pharmaceutical compositions thereof are inhibitors of one, or both of, .alpha.v.beta..sub.1 integrin and .alpha.v.beta..sub.6 integrin that are useful for treating fibrosis such as in nonalcoholic steatohepatitis (NASH), idiopathic pulmonary fibrosis (IPF) and nonspecific interstitial pneumonia (NSIP).