Polyphor AG
Beta-hairpin peptidomimetics

Abstract:

Beta-hairpin peptidomimetics of the general formula (I), cyclo[P.sup.1--P.sup.2--P.sup.3--P.sup.4--P.sup.5--P.sup.6--P.sup.7--P.su- p.8--P.sup.9--P.sup.10--P.sup.11--P.sup.12-T.sup.1-T.sup.2], and pharmaceutically acceptable salts thereof, with P.sup.1 to P.sup.12, T.sup.1 and T.sup.2 being elements as defined in the description and the claims, have broad spectrum Gram-negative antimicrobial activity to e.g. inhibit the growth or to kill microorganisms such as Klebsiella pneumoniae and/or Acinetobacter baumannii and/or Escherichia coli. They can be used as medicaments to treat or prevent infections or as disinfectants for foodstuffs, cosmetics, medicaments or other nutrient-containing materials. These peptidomimetics can be manufactured by a process which is based on a mixed solid- and solution phase synthetic strategy.