Polyphor AG
Beta-hairpin peptidomimetics

Abstract:

Beta-hairpin peptidomimetics of the general formula (I), cyclo[P.sup.1-P.sup.2-P.sup.3-P.sup.4-P.sup.5-P.sup.6-P.sup.7-P.sup.8-P.s- up.9-P.sup.10-P.sup.11-P.sup.12-T.sup.1-T.sup.2], and pharmaceutically acceptable salts thereof, with P.sup.1 to P.sup.12, T.sup.1 and T.sup.2 being elements as defined in the description and the claims, have Gram-negative antimicrobial activity to e.g. inhibit the growth or to kill microorganisms such as Klebsiella pneumoniae and/or Acinetobacter baumannii and/or Escherichia coli. They can be used as medicaments to treat or prevent infections or as disinfectants for foodstuffs, cosmetics, medicaments or other nutrient-containing materials. These peptidomimetics can be manufactured by a process which is based on a mixed solid- and solution phase synthetic strategy.