Protagonist Therapeutics, Inc.
NOVEL a4B7 PEPTIDE MONOMER AND DIMER ANTAGONISTS
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Abstract:
The invention relates to peptide dimer compounds and peptide monomer compounds that potently inhibit binding of .alpha.4.beta.7 to the mucosal addressin cell adhesion molecule (MAdCAM) in vivo, possess high selectivity against .alpha.4.beta.1 binding, and have high stability under gastrointestinal conditions.
Status:
Application
Type:
Utility
Filling date:
4 Feb 2020
Issue date:
1 Oct 2020