Ultragenyx Pharmaceutical Inc.
ENGINEERED PRODUCER CELL LINES AND METHODS OF MAKING AND USING THE SAME

Abstract:

This application relates to recombinant adeno-associated virus (rAAV) packaging and/or producer cell lines which have been engineered to reduce expression and/or activity of one or more genes and/or proteins to increase rAAV titers. The methods of generating the engineered cell lines have also been described herein.