Arcus Biosciences, Inc.
Quinazoline-pyrazole derivatives for the treatment of cancer-related disorders

Abstract:

A compound that is an inhibitor of at least one of the A.sub.2A and A.sub.2B adenosine receptors having Formula (I) ##STR00001## and compositions containing the compound and methods for synthesizing the compound, are described herein. The use of such compound and compositions for the treatment of a diverse array of diseases, disorders, and conditions, including cancer- and immune-related disorders that are mediated, at least in part, by the adenosine A.sub.2A receptor and/or the adenosine A.sub.2B receptor.