Arcus Biosciences, Inc.
PROCESSES FOR PREPARING AMINOPYRIMIDINE COMPOUNDS

Abstract:

Provided herein are improved processes for preparing aminopyrimidine compounds of Formula (I). The disclosed processes advantageously proceed through a .beta.-diketoester intermediate of Formula (A) and avoid the direct linking of a pyrimidine and phenyl moieties. The disclosed methods significantly increase yield of the desired compounds and simplifies the synthetic route.