Dr. Reddy's Laboratories Limited
PROCESS FOR ENANTIOSELECTIVE ENZYMATIC REDUCTION OF KETO COMPOUNDS

Abstract:

The present application relates to enantioselective enzymatic reduction of keto compounds to the corresponding chiral hydroxy compounds. Specifically the present application describes enantioselective enzymatic reduction of ethyl-4-chloroacetoacetate (compound of formula I) into (R)-ethyl-4-chloro-3-hydroxybutyrate (compound of formula II). The present application also covers use of (R)-ethyl-4-chloro-3-hydroxybutyrate prepared by the enantioselective enzymatic reduction process in the preparation of SGLT2 inhibitor empaglifiozin. ##STR00001##