Dr. Reddy's Laboratories Limited
Solid dispersions of amorphous Lumateperone p-Tosylate

Abstract:

The present application relates to solid state forms of Lumateperone p-Tosylate and processes for preparation thereof. The present application provides amorphous Lumateperone p-tosylate and a solid dispersion comprising amorphous Lumateperone p-tosylate and one or more pharmaceutically acceptable polymers and processes for preparation thereof. The compounds are useful as 5-HT.sub.2 receptor agonists and antagonists used in treating disorders of the central nervous system including a disorder associated with 5HT.sub.2C or 5HT.sub.2A receptor modulation.