Regeneron Pharmaceuticals, Inc.
NON-HUMAN ANIMALS HAVING A HUMANIZED SIGNAL-REGULATORY PROTEIN GENE

Abstract:

Genetically modified non-human animals and methods and compositions for making and using the same are provided, wherein the genetic modification comprises a humanization of an endogenous signal-regulatory protein gene, in particular a humanization of a SIRP.alpha. gene. Genetically modified mice are described, including mice that express a human or humanized SIRP.alpha. protein from an endogenous SIRP.alpha. locus.