Regeneron Pharmaceuticals, Inc.
METHODS OF REDUCING POLYSORBATE DEGRADATION IN DRUG FORMULATIONS

Abstract:

The present disclosure pertains to compositions with reduced residual amount of lipases and methods of making such compositions. In particular, it pertains to compositions and methods of such making compositions by depleting the compositions of certain lipases, such as, liver carboxylesterase B-1-like protein and liver carboxylesterase 1-like protein.