Regeneron Pharmaceuticals, Inc.
TARGET INTERFERENCE MITIGATION IN ANTI-DRUG ANTIBODY ASSAY

Abstract:

The present invention provides methods and systems to detect, quantify or characterize anti-drug antibodies which are induced by the administration of pharmaceutical products. The methods and systems include the use of a binding partner of a target and/or a co-factor to improve the detection of anti-drug antibodies in serum samples in the presence of soluble targets based on competitive target binding. The methods and systems also include the use of immuno-depletion to improve the detection.