Regeneron Pharmaceuticals, Inc.
High affinity antibodies to human IL-6 receptor
Last updated:
Abstract:
A human antibody or an antigen-binding fragment which binds human IL-6 receptor (hIL-6R) with a K.sub.D of about 500 pM or less and blocks IL-6 activity with an IC.sub.50 of 200 pM or less, is provided. In preferred embodiments, the antibody the antibody or antigen-binding fragment binds hIL-6R with an affinity at least 2-fold higher relative to its binding monkey IL-6R.
Status:
Grant
Type:
Utility
Filling date:
28 Jan 2020
Issue date:
28 Jun 2022