Regeneron Pharmaceuticals, Inc.
Rodent Model Of Increased Bone Mineral Density

Abstract:

The present disclosure provides rodent models of increased bone mineral density and/or bone mineral content, genetically modified rodents and isolated rodent cells or tissues having a disruption of one or both alleles of the Zinc and Ring Finger 3 (Znrf3) gene, knockout rodent Znrf3 DNA constructs, methods of producing genetically modified rodents, methods of producing Znrf3 knockout rodents, and methods of determining the effect of an agent for treating low bone mineral density and/or bone mineral content.