Regeneron Pharmaceuticals, Inc.
Compositions and Methods for Enhancing Body Weight and Lean Muscle Mass Using Antagonists Against Leptin Receptor, GDF8 and Activin A

Abstract:

The present invention provides combinations including antagonists of leptin receptor, GDF8 and Activin A and methods of use thereof. Such compositions are effective for example for causing an increase in lean body mass, at least in part, at the expense of fat mass. Methods for treating malnutrition, cachexia and other conditions characterized by insufficient nutrition and weight loss are also provided.