Regeneron Pharmaceuticals, Inc.
Genetically modified rat comprising a humanized TRKB locus
Last updated:
Abstract:
Non-human animal genomes, non-human animal cells, and non-human animals comprising a humanized TRKB locus and methods of making and using such non-human animal genomes, non-human animal cells, and non-human animals are provided. Non-human animal cells or non-human animals comprising a humanized TRKB locus express a human TRKB protein or a chimeric transthyretin protein, fragments of which are from human TRKB. Methods are provided for using such non-human animals comprising a humanized TRKB locus to assess in vivo efficacy of human-TRKB-targeting reagents such as nuclease agents designed to target human TRKB.
Status:
Grant
Type:
Utility
Filling date:
30 Nov 2018
Issue date:
23 Aug 2022