Regeneron Pharmaceuticals, Inc.
Concentration-dependent self-interaction assay
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Abstract:
Methods for producing high concentration protein formulations having high stability are provided. Assays for selecting proteins and formulation conditions that have high self-repulsive attributes are used as an early step in the manufacturing process. Specifically, a protein concentration-dependent self-interaction nanoparticle spectroscopy method is employed as a protein colloidal interaction assay.
Status:
Grant
Type:
Utility
Filling date:
18 Aug 2017
Issue date:
30 Aug 2022