Regeneron Pharmaceuticals, Inc.
Concentration-dependent self-interaction assay

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Abstract:

Methods for producing high concentration protein formulations having high stability are provided. Assays for selecting proteins and formulation conditions that have high self-repulsive attributes are used as an early step in the manufacturing process. Specifically, a protein concentration-dependent self-interaction nanoparticle spectroscopy method is employed as a protein colloidal interaction assay.

Status:
Grant
Type:

Utility

Filling date:

18 Aug 2017

Issue date:

30 Aug 2022