TREATMENT OF OCULAR DISEASES WITH HUMAN POST-TRANSLATIONALLY MODIFIED VEGF-TRAP

Abstract:

Compositions and methods are described for the delivery of a fully human post-translationally modified (HuPTM) therapeutic VEGF-Trap (VEGF-Trap.sup.HuPTM)--to a human subject diagnosed with an ocular disease or condition or cancer associated with neovascularization and indicated for treatment with the therapeutic mAb. Delivery may be advantageously accomplished via gene therapy--e.g., by administering a viral vector or other DNA expression construct encoding the VEGF-Trap.sup.HuPTM to a patient (human subject) diagnosed with an ocular condition or cancer indicated for treatment with the VEGF-Trap--to create a permanent depot in a tissue or organ of the patient that continuously supplies the VEGF-Trap.sup.HuPTM, i.e., a human-glycosylated transgene product. Alternatively, the VEGF-Trap.sup.HuPTM, for example, produced in cultured human cell culture, can be administered to the patient for treatment of the ocular disease or cancer.