Rigel Pharmaceuticals, Inc.
2,3-Disubstituted Pyridine Compounds as TGF-Beta Inhibitors and Methods of Use

Abstract:

The invention described herein comprises compounds and a method of treating cancer comprising administering to a subject having cancer one of the compounds in conjunction with another therapeutic treatment of cancer. The compounds inhibit signaling by a member of the TGF-.beta. superfamily such as Nodal or Activin