Rigel Pharmaceuticals, Inc.
TGF-beta inhibitors

Abstract:

Disclosed are imidazole and thiazole compounds, as well as pharmaceutical compositions and methods of use thereof. One embodiment is a compound having the structure ##STR00001## and pharmaceutically acceptable salts, prodrugs and N-oxides thereof (and solvates and hydrates thereof), wherein X, A, Z, R.sup.1 and R' are as described herein. In certain embodiments, a compound disclosed herein inhibits TGF-.beta., and can be used to treat disease by blocking TGF-.beta. signaling.