Prometheus Biosciences, Inc.
METHODS FOR PREDICTION OF ANTI-TNF ALPHA DRUG LEVELS AND AUTOANTIBODY FORMATION

Abstract:

In some aspects, the present invention provides methods for predicting whether a subject will develop autoantibodies to an anti-TNF drug during the course of anti-TNF.alpha. drug therapy. In other aspects, the present invention provides methods for predicting the level of an anti-TNF.alpha. drug in a subject during the course of anti-TNF.alpha. drug therapy. Systems for predicting anti-TNF.alpha. drug levels and the likelihood of autoantibody formation during the course of anti-TNF.alpha. drug therapy are also provided herein. The present invention further provides methods for predicting a clinical outcome (e.g., endoscopic response) of a subject on anti-TNF.alpha. drug therapy.