Sage Therapeutics, Inc.
9(11)-UNSATURATED NEUROACTIVE STEROIDS AND THEIR METHODS OF USE

Abstract:

Provided herein is a compound of Formula (I) or a pharmaceutically acceptable salt thereof, wherein n, R.sup.19, R.sup.5, R.sup.3, R.sup.6a, R.sup.6b, R.sup.2a, R.sup.2b, R.sup.4a, R.sup.4b, R.sup.7a, R.sup.7b, R.sup.11, R.sup.12a, R.sup.12b, R.sup.16, R.sup.21a, R.sup.21b, and R.sup.21c are defined herein. Also provided herein are pharmaceutical compositions comprising a compound of Formula (I) and methods of using the compounds, e.g., in the treatment of CNS-related disorders. ##STR00001##