Silverback Therapeutics, Inc.
TGF R1 INHIBITOR-ASGR ANTIBODY CONJUGATES AND USES THEREOF

Abstract:

Various conjugates and compositions thereof are disclosed for use in the treatment of a liver disease, such as liver cancer and liver fibrosis. The compositions comprise conjugates, wherein the conjugates are comprised of an antibody or antibody construct specific for ASGR1 or ASGR2 attached to a TGF.beta.R1 inhibitor via a linker. Additionally provided are the methods of preparation of the conjugates and compositions thereof.