Seagen Inc.
Anti-TIGIT antibodies
Last updated:
Abstract:
Isolated antibodies that bind to human TIGIT (T-cell immunoreceptor with Ig and ITIM domains) are provided. In some embodiments, the antibody has a binding affinity (K.sub.D) for human TIGIT of less than 5 nM. In some embodiments, the anti-TIGIT antibody blocks binding of CD155 and/or CD112 to TIGIT. In some embodiments, the antibodies are afucosylated.
Status:
Grant
Type:
Utility
Filling date:
22 Aug 2019
Issue date:
2 Aug 2022