Sangamo Therapeutics, Inc.
GIN RECOMBINASE VARIANTS

Abstract:

The present disclosure provides a Gin recombinase catalytic domain variant and a zinc finger recombinase comprising a Gin recombinase catalytic domain variant operatively linked to a zinc finger nucleotide binding domain and methods for modifying the genome of a cell or to treat a disorder in a subject by using said zinc finger recombinase protein.