Sanofi
NEURONAL CELL PROTECTIVE EFFECT OF ANTIBODIES SPECIFIC FOR THE PROTOFIBRILLAR FORM OF THE BETA-AMYLOID PEPTIDE

Abstract:

The present invention relates to an antibody specific for the protofibrillar form of the A.beta. peptide for use in the prevention and/or the treatment of a neurodegenerative disease involving A.beta. peptide aggregation, in particular for the prevention of Alzheimer's disease and/or the treatment of an early stage of symptomatic Alzheimer's disease. The antibody may thus be used before the appearance of memory loss and impaired cognitive functions or at the earliest stages of the disease. Said antibody has indeed a neuronal cell protective effect against A.beta. peptide-induced neurotoxicity.