Sanofi
MODIFIED LIPIDATED RELAXIN B CHAIN PEPTIDES AND THEIR THERAPEUTIC USE

Abstract:

The present invention relates to a biologically active single chain Relaxin peptide having the following formula (I) (SEQ ID NO 105): N.sub.ter-Ac-X.sub.10-E-G-R-E-X.sub.15-V-R-X.sub.18-X.sub.19-I-X.sub.21-- X.sub.22-E-G-X.sub.25-S-X.sub.27-X.sub.28-X.sub.29-X.sub.30--X.sub.31--X.s- ub.32--X.sub.33--NH.sub.2--C.sub.ter or a salt or solvate thereof. It also concerns a pharmaceutical composition comprising at least one peptide of the invention, and the peptide or the pharmaceutical composition for its use as a medicament.