Sanofi
Modified lipidated Relaxin B chain peptides and their therapeutic use

Abstract:

Provided is a biologically active single chain Relaxin peptide having the following formula (I): N.sub.ter-Ac-(E).sub.a-X.sub.10-E-G-R-E-X.sub.15-V-R-X.sub.18-X.sub.19-I-- X.sub.21-X.sub.22-E-G-X.sub.25-S-X.sub.27-X.sub.28-X.sub.29-X.sub.30-R-(X.- sub.32).sub.b-(X.sub.33).sub.c-(K).sub.d-(X.sub.35).sub.e-(gE).sub.f-X.sub- .37-C.sub.ter; or a salt or solvate thereof. Also provided is a pharmaceutical composition comprising at least one peptide of the invention, and the peptide or the pharmaceutical composition for its use as a medicament.