Sanofi
Modified lipidated Relaxin B chain peptides and their therapeutic use

Abstract:

Provided is a biologically active single chain Relaxin peptide having the following formula (I) (SEQ ID NO 105): N.sub.ter-Ac-X.sub.10-E-G-R-E-X.sub.15-V-R-X.sub.18-X.sub.19-I-X.sub.21-X- .sub.22-E-G-X.sub.25-S-X.sub.27-X.sub.28-X.sub.29-X.sub.30-X.sub.31-X.sub.- 32-X.sub.33-NH.sub.2-C.sub.ter or a salt or solvate thereof. Also provided is a pharmaceutical composition comprising at least one biologically active single chain Relaxin peptide. Uses of the peptide or the pharmaceutical composition as a medicament are also provided.