Sanofi
Immunogenic compositions against S. aureus

Abstract:

The invention relates to a conjugate of a saccharide covalently bound to a carrier protein, wherein the saccharide comprises repetitive units of 1,5 ribitol phosphate in which all the ribitol residues are substituted by N-acetyl D-glucosaminyl residues at the 4-position, and wherein said N-acetyl D-glucosaminyl residues are exclusively in anomeric configuration .alpha. or are exclusively in anomeric configuration .beta. and wherein the carrier protein provides at least one epitope to the conjugate which is recognized by T helper lymphocytes.