Sanofi
Fused pentacyclic imidazole derivatives as modulators of TNF activity

Abstract:

A series of substituted fused pentacyclic benzimidazole derivatives, and analogues thereof, being potent modulators of human TNF.alpha. activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including autoimmune and inflammatory disorders; neurological and neurodegenerative disorders; pain and nociceptive disorders; cardiovascular disorders; metabolic disorders; ocular disorders; and oncological disorders.