Sanofi
Novel Substituted 6,7-Dihydro-5H-Benzo[7]Annulene Compounds, Processes for their Preparation and Therapeutic Uses Thereof

Abstract:

Compounds of formula (I): ##STR00001## wherein R1 and R2 represent hydrogen or deuterium atoms; R3 represents a hydrogen atom or a --COOH, a --OH or a --OPO(OH).sub.2 group; R4 represents a hydrogen atom or a fluorine atom; R5 represents a hydrogen atom or a --OH group; wherein at least one of R3 or R5 is different from a hydrogen atom; when R3 represents a --COOH, --OH or --OPO(OH).sub.2 group, then R5 represents a hydrogen atom; when R5 represents a --OH group, then R3 and R4 represent hydrogen atoms; and R6 is selected from an optionally substituted phenyl, heteroaryl, cycloalkyl and heterocycloalkyl group; and the preparation and the therapeutic uses of the compounds of formula (I) as inhibitors and degraders of estrogen receptors, useful especially in the treatment of cancer.