Spero Therapeutics, Inc.
POLYMYXIN DERIVATIVES AND THEIR USE IN COMBINATION THERAPY TOGETHER WITH DIFFERENT ANTIBIOTICS

Abstract:

Provided are compounds of formula (III), and the use of compounds of formula (III) in methods of treatment, such as methods of treating a microbial infection. The compounds of formula (III) is: where --R.sup.15 is an amino-containing group: and --R.sup.1, --R.sup.2, --R.sup.3, --R.sup.4, --R, --R.sup.A, Q, --R.sup.16, --R.sup.17 are as described in further detail in the description. ##STR00001##