Spero Therapeutics, Inc.
COMPOUNDS

Abstract:

The invention provides a polymyxin compound of formula (I) and salts, solvates and protected forms thereof, pharmaceutical compositions comprising the compounds of formula (I), and the use of the compounds and compositions in methods of treatment, such as methods for the treatment of microbial infections. The compounds of formula (I) are represented thus: ##STR00001## wherein --R.sup.15 is a group: ##STR00002## and --R.sup.16 is hydrogen; --R.sup.17 is hydrogen -L- is a covalent bond or methylene; and --Ar is optionally substituted aryl. The groups --X--, --R.sup.1, --R.sup.2, --R.sup.3, --R.sup.4, and --R.sup.8 are as defined herein.