SQZ Biotechnologies Company
INTRACELLULAR DELIVERY OF BIOMOLECULES TO MODULATE ANTIBODY PRODUCTION

Abstract:

The present invention provides methods and systems for modulating antibody production by passing a cell suspension through a constriction, wherein the constriction deforms the cell thereby causing a perturbation of the cell such that a compound that modulates antibody production enters the cell. In some embodiments, the invention provides methods and systems for inducing de novo antibody production in cells.