Surmodics, Inc.
ACTIVE AGENT DEPOTS FORMED IN SITU
Last updated:
Abstract:
Embodiments herein relate to active agent depots formed in situ and related methods. In various embodiments, a method of forming an active agent depot in situ is included. The method can include contacting a composition with a vessel wall, wherein the composition includes an active agent and a fibrin promoting vessel wall transfer agent wherein the ratio of active agent to fibrin promoting vessel wall transfer agent (wt./wt.) is at least 5:1. The method also includes transferring the composition from a device surface to the vessel wall surface. The method also includes forming a fibrin matrix around the composition. Other embodiments are also included herein.
Status:
Application
Type:
Utility
Filling date:
30 Sep 2020
Issue date:
1 Apr 2021