Sorrento Therapeutics, Inc.
METHOD FOR ADMINISTERING A MEDICAMENT SUITABLE FOR TREATING A MIGRAINE OR CLUSTER HEADACHE

Abstract:

A method for administering a medicament suitable for treating a migraine or cluster headache to a patient in need thereof includes placing a mounting surface of a fluid delivery apparatus with the medicament in contact with at least a portion of the skin of said patient. A flow rate of the medicament from the fluid delivery apparatus is adjusted such that the medicament is delivered to the patient for at least a predetermined time period. The fluid delivery apparatus includes a controller assembly having a body component defining an axis and a plunger component slidably coupled to the body component. The plunger is positionable between a first position in which the plunger is nearest to the body component and a second position in which the plunger component is furthest from the body component. A bias assembly is positioned between the body component and the plunger component. The bias assembly is configured to apply a two stage force profile to the plunger component. Also disclosed is method for administering a medicament to a patient in need thereof such that the C.sub.max, T.sub.max and AUC are within predetermined, therapeutically effective values. Such methods are effective in treating migraine and cluster headaches with sumatriptan or other medicament.