Syros Pharmaceuticals, Inc.
COMPOSITIONS AND METHODS FOR TREATING CANCERS WITH COVALENT INHIBITORS OF CYCLIN-DEPENDENT KINASE 7 (CDK7)

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Abstract:

The present invention relates to methods of identifying subjects suffering from various types of cancer who are more likely to respond to treatment with a covalent CDK7 inhibitor, such as N-((1S,3R)-3-(5-chloro-4-(1H-indol-3-yl)pyrimidin-2-ylamino)-1-methylcycl- ohexyl)-5-((E)-4-(dimethylamino)but-2-enamido)picolinamide (Compound 1), either alone or in combination with other classes of anti-cancer therapies based on the presence or absence of certain biomarkers. In addition, the present invention relates to combinations of Compound 1 and one or more other anti-cancer therapies, kits containing them, and the use of such combinations in treating subjects suffering from various types of cancers.

Status:
Application
Type:

Utility

Filling date:

12 Jun 2018

Issue date:

16 Apr 2020