Takeda Pharmaceutical Company Limited
Method for producing sulfonyl chloride compound

Abstract:

An object of the present invention is to provide a production method of an intermediate used in the production method of a sulfonylpyrrole compound useful as a pharmaceutical product. The present invention relates to a method of producing sulfonylpyrrole compound (VI) by reacting a pyridine-3-sulfonic acid compound with phosphorus pentachloride in a solvent of chlorobenzene or trifluoromethylbenzene to give a pyridine-3-sulfonyl chloride compound, reacting the compound without isolation with compound (III) to give compound (IV), and subjecting the compound (IV) to a reductive amination reaction. ##STR00001## wherein R.sup.2 is a hydrocarbon group etc. and R.sup.3 and R.sup.4 are each a hydrogen atom etc., ##STR00002## wherein R.sup.2 is an optionally substituted pyridin-3-yl group, and the other symbols are as defined above, ##STR00003## wherein R.sup.5 is an alkyl group and the other symbols are as defined above.