Takeda Pharmaceutical Company Limited
DRUG ADMINISTRATION METHOD

Abstract:

The present invention provides a safer novel opening system with highly broad utility for a blood-brain barrier (BBB), containing nano-bubble water or nano-bubble aqueous solution containing nano-bubbles having an average diameter of not more than 200 nm, and an ultrasound generating apparatus in combination; a method for opening BBB, including using the nano-bubble water or nano-bubble aqueous solution, and an ultrasound; and a method for increasing BBB permeability of a drug, including using the nano-bubble water or nano-bubble aqueous solution, and an ultrasound.