Takeda Pharmaceutical Company Limited
TREATMENT OF GASTROPARESIS WITH TRIAZASPIRO[4.5]DECANONE

Abstract:

Provided herein is a method of treating or alleviating one or more symptoms of a disorder, disease, or condition mediated by a dopamine D.sub.2 or D.sub.3 receptor with 3-((1-cyclohexyl-4-oxo-8-(4-oxo-4-phenylbutyl)-1,3,8-triazaspiro[4.5]deca- n-3-yl)methyl)benzoic acid or a pharmaceutically acceptable salt thereof. Also provided herein is a method of increasing the scrum prolactin level with 3-((1-cyclohexyl-4-oxo-8-(4-oxo-4-phenylbutyl)-1,3,8-triazaspiro[4.5- ]decan-3-yl)methyl)benzoic acid or a pharmaceutically acceptable salt thereof.