Takeda Pharmaceutical Company Limited
CATIONIC LIPID

Abstract:

The present invention provides a technique capable of transferring an active ingredient, particularly, a nucleic acid, to a cell with excellent efficiency and a cationic lipid for use in this technique, etc. The cationic lipid of the present invention is a compound represented by the formula (I) or a salt thereof. n1 represents an integer of 2 to 6, n2 represents an integer of 0 to 2, n3 represents an integer of 0 to 2, L represents --C(O)O-- or --NHC(O)O--, Ra represents a linear C.sub.5-13 alkyl group, a linear C.sub.13-17 alkenyl group or a linear C.sub.17 alkadienyl group, Rb represents a linear C.sub.2-9 alkyl group, Rc represents a hydrogen atom or a linear C.sub.2-9 alkyl group, Rd represents a hydrogen atom or a linear C.sub.2-9 alkyl group, Re represents a linear C.sub.2-9 alkyl group, and Rf represents a linear C.sub.2-9 alkyl group. ##STR00001##