Telesis Bio, Inc.
Polyanionic delivery of nucleic acids

Abstract:

Disclosed are dendritic anionic lipids which are compounds of Formula (I): wherein R and R.sup.1 are non-polar groups, L is a linking moiety, and Dm is a dendritic moiety of m generations, each as defined herein. These dendritic anionic lipids are useful for delivery and expression of m RNA and encoded protein, e.g., as a component of liposomal delivery vehicle, and accordingly can be useful for treating various diseases, disorders and conditions, such as those associated with deficiency of one or more proteins. ##STR00001##