Theratechnologies Inc.
PHARMACEUTICAL COMPOSITIONS OF GHRH ANALOGS AND USES THEREOF

Abstract:

A pharmaceutical composition comprising a GHRH molecule or a pharmaceutically acceptable salt thereof is described, as well as uses thereof and a kit for preparing such a pharmaceutical composition. In an embodiment, GHRH molecule or pharmaceutically acceptable salt thereof is trans-3-hexenoyl-GHRH.sub.(1-44)-NH.sub.2 or a pharmaceutically acceptable salt thereof. In an embodiment, a pharmaceutical composition comprising about 1.3 to about 1.5 mg of a GHRH molecule such as trans-3-hexenoyl-GHRH.sub.(1-44)-NH.sub.2 at a concentration of about 3.5 mg/mL or more, as well as uses thereof and a kit for preparing such a pharmaceutical composition, are described. Uses of such a pharmaceutical composition to obtain plasmatic levels of e.g., trans-3-hexenoyl-GHRH.sub.(1-44)-NH.sub.2 that are bioequivalent to administration of 2 mg of trans-3-hexenoyl-GHRH.sub.(1-44)-NH.sub.2 at a concentration of 1 mg/mL in a subject are also described.