10x Genomics, Inc.
SYSTEMS AND METHODS FOR IDENTIFYING FEATURE LINKAGES IN MULTI-GENOMIC FEATURE DATA FROM SINGLE-CELL PARTITIONS

Abstract:

Methods and systems for generating linkage correlations and linkage significances between a first genomic feature and a second genomic feature identified for each of a plurality of cells may be provided. For example, the method may comprise receiving a data matrix comprising a first genomic feature and a second genomic feature identified for each of a plurality of cells; smoothing the data matrix to generate a smoothed matrix; generating linkage correlations between the first genomic feature and second genomic feature identified for each of the plurality of cells in the data matrix; generating linkage significances using multiplication of a plurality of linkage matrixes; and outputting the linkage correlations and linkage significances for each of the plurality of cells in the data matrix.