Vaccinex, Inc.
COMBINED INHIBITION OF SEMAPHORIN-4D AND TGF-BETA AND COMPOSITIONS THEREFOR

Abstract:

Provided herein are methods for inhibiting, delaying, or reducing tumor growth and metastases of plexin-B1, plexin-B2, and/or CD72-expressing cancer cells in a subject, comprising administering to the subject an effective amount of an isolated binding molecule which specifically binds to semaphorin-4D (SEMA4D) in combination with an effective amount of antibody or antigen-binding fragment thereof that inhibits TGF.beta., and, optionally, at least one other immune modulating therapy.