Vaccinex, Inc.
Use of semaphorin-4D inhibitory molecules with an immune modulating therapy to inhibit tumor growth and metastases

Abstract:

Provided herein are methods for inhibiting, delaying, or reducing tumor growth and metastases of Plexin-B1-expressing cancer cells in a subject, comprising administering to the subject an effective amount of an isolated binding molecule which specifically binds to semaphorin-4D (SEMA4D) in combination with an effective amount of at least one other immune modulating therapy.