Vertex Pharmaceuticals Incorporated
STEM CELL DERIVED ISLET DIFFERENTIATION

Abstract:

Provided herein are methods of producing .beta. cells and precursors thereof utilizing a Wnt signaling inhibitor or PKC activator, or both. Also provided herein are in vitro cultures comprising said cells, methods of treating a subject with a disease characterized by high blood sugar levels over a prolonged period of time by administering said cells, and devices for encapsulating said cells.