Voyager Therapeutics, Inc.
Closed-ended linear duplex DNA for non-viral gene transfer
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Abstract:
Aspects of the disclosure relate to a nucleic acid comprising a heterologous nucleic acid insert flanked by interrupted self-complementary sequences, wherein one self-complementary sequence is interrupted by a cross-arm sequence forming two opposing, lengthwise-symmetric stem-loops, and wherein the other of the self-complementary sequences is interrupted by a truncated cross-arm sequence. Methods of delivering the nucleic acid to a cell are also provided.
Status:
Grant
Type:
Utility
Filling date:
3 Mar 2017
Issue date:
20 Jul 2021