Voyager Therapeutics, Inc.
ENGINEERED UNTRANSLATED REGIONS (UTR) FOR AAV PRODUCTION
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Abstract:
The present disclosure describes methods and systems for use in the production of recombinant adeno-associated virus (rAAV) particles. In certain embodiments, the production process and system include engineered untranslated regions (UTR) which allow for the controlled expression of AAV capsid proteins, such as VP1, VP2 and VP3. In certain embodiments, the production process and system include engineered untranslated regions (UTR) which allow for the controlled expression of non-structural AAV replication proteins, such as Rep78 and Rep52.
Status:
Application
Type:
Utility
Filling date:
13 Jun 2019
Issue date:
30 Sep 2021